Job Description

Job Summary:

The Department of Biomolecular Chemistry is a part of the School of Medicine and Public Health. Its research focuses on understanding the molecular underpinnings of biological processes, particularly as it relates to human disease. Research in the department spans a broad range of questions and methodologies, including DNA replication, chromatin structure, gene expression, protein and membrane trafficking, cell signaling and metabolism, cancer, embryogenesis, and pathogenesis. The department is housed within the Hector Deluca Biochemical Sciences complex, a state-of-the-art research and instructional complex located on Henry Mall, and has a reputation for carrying out federally funded, high level, competitive biomedical research. Visit to learn more.

The Engin Laboratory within the Department of Biomolecular Chemistry (BMC) is focused on understanding how cellular stress response and organelle dysfunction plays a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, lysosome dysfunction, cellular senescence and the crosstalk between stressed beta cells and immune cells. The work involves working with the beta cell or immune cell-specific mouse models of the unfolded protein response pathway and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al, Cell Metab 2020, Chen, et al., Nat Comm 2022). More information about our research and publications can be found at enginlab.org .

The Research Scientist will play key roles in identifying research problems and developing research methodologies and procedures, implementing in vitro and in vivo experiments and training students. The Scientist will work on understanding the endoplasmic reticulum stress in beta cells of genetically engineered mouse and human islets. ER-mitochondria crosstalk and senescence will also be investigated in these models. Beta cell-immune cell communication and well as immune cell cellular stress responses are also the research areas that the lab works on. Hence, combination on of in vivo and ex vivo studies, single cell analysis of these systems as well as multidisciplinary approaches are routinely used in the lab.

Candidates should have demonstrated ability to work effectively in a collaborative manner with faculty and staff, as well as other institutional representatives; strong organizational, written, and verbal communication skills in English; high levels of critical thinking, excellent technical skills, and a strong track-record of accomplishment and productivity in research as evidenced by high-quality publications related to physiology, immunology, metabolism, cell signaling/signal transduction and disease mechanisms.

Responsibilities:

Identifies research problems, designs research methodologies, performs research, and helps to prepare the results for presentation to professional organizations or for scholarly publications to help advance research.

• 5% Assists with the identification of research problems and the development of research methodologies and procedures
• 70% Collects and analyzes research data, conducts experiments and interviews, and documents results according to established policies and procedures under general supervision and limited responsibility
• 10% Conducts literature reviews, prepares reports and materials, and disseminates information to appropriate entities
• 5% Attends and assists with the facilitation of scholarly events and presentations in support of continued professional development and the dissemination of research information
• 5% Writes or assists in developing grant applications and proposals to secure research funding
• 5% Serves as a main point of contact and liaison with internal and external stakeholders providing information and representing the interests of a specialized research area

Institutional Statement on Diversity:

Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals.

The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world.

For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion

Education:

Required
PhD in biology, biochemistry, or other closely related field required by application date

Qualifications:

- 3 years minimum of post-doctoral research experience in molecular biology, cell or organelle biology, or immunology in an academic or similar research environment is required.
- Demonstrated potential for excellence in of these fields is highly desired: Senescence, stress responses, immune diseases, organelle biology, cell heterogeneity.
- Prior experience on working with mouse models is required.
- Productivity evidenced by at least 2 first-author papers or preprints in the last 5 years is required.
- Expertise in two or more of following skills/techniques is highly desired:
* Pancreas biology: Islet isolation, human islet culturing and experimenting, islet histomorphometry.
* Immunology: Multicolor FACS analysis, FlowJo analysis, adoptive transfers.
* Prior experience on handling large data sets and bioinformatic analysis

Work Type:

Full Time: 100%

It is anticipated this position requires work be performed in-person, onsite, at a designated campus work location.

Appointment Type, Duration:

Ongoing/Renewable

Salary:

Minimum $60,000 ANNUAL (12 months)
Depending on Qualifications
Employees in this position can expect to receive benefits such as generous vacation, holidays, and sick leave; competitive insurances and savings accounts; retirement benefits. Benefits information can be found at ().

How to Apply:

To apply for this position, please click on the "Apply Now" button. You will be asked to upload a current resume/CV and a cover letter briefly describing your qualifications and experience. You will also be asked to provide contact information for three (3) references, including your current/most recent supervisor during the application process. References will not be contacted without prior notice.

Contact:

Feyza Engin
[email protected]
608-262-8667
Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information.

Official Title:

Scientist I(RE043)

Department(s):

A53-MEDICAL SCHOOL/BIOMOLEC CHEM/BIOMOL CHM

Employment Class:

Academic Staff-Renewable

Job Number:

309439-AS

The University of Wisconsin-Madison is an Equal Opportunity and Affirmative Action Employer.

Qualified applicants will receive consideration for employment without regard to, including but not limited to, race, color, religion, sex, sexual orientation, gender identity, national origin, age, pregnancy, disability, or status as a protected veteran and other bases as defined by federal regulations and UW System policies. We promote excellence through diversity and encourage all qualified individuals to apply. For more information regarding applicant and employee rights and to view federal and state required postings, click here

If you need to request an accommodation because of a disability, you can find information about how to make a request at the following website:

Employment may require a criminal background check. It may also require you and your references to answer questions regarding sexual violence and sexual harassment.

The University of Wisconsin System will not reveal the identities of applicants who request confidentiality in writing, except that the identity of the successful candidate will be released. See Wis. Stat. sec. 19.36(7).

The Annual Security and Fire Safety Report contains current campus safety and disciplinary policies, crime statistics for the previous 3 calendar years, and on-campus student housing fire safety policies and fire statistics for the previous 3 calendar years. UW-Madison will provide a paper copy upon request; please contact the University of Wisconsin Police Department .

About University of Wisconsin–Madison

Work with purpose, make an impact, and grow your career. The University of Wisconsin–Madison is committed to equity, inclusion and employee well-being as we proudly work to improve the lives of people in Wisconsin and beyond. Join a world-class educational and research institution, located in one of America's best places to live and work. The University of Wisconsin–Madison has been a catalyst for the extraordinary since its founding in 1848. As a public land-grant university and prolific research institution, our guiding principle is the Wisconsin Idea, a long-standing commitment to conducting outreach that contributes to a better future for our state, our nation, and the world. In a survey of working Americans conducted by Forbes, UW?Madison ranked among the top 100 America’s Best Large Employers in 2022. Our location in Madison, Wisconsin, is consistently rated one of the best places to live in the United States. A variety of independent rankings place Madison among the best U.S. cities for livability, work-life balance, fitness, opportunities for women, best places to raise children, and other measures. We were also named one of the Best Universities for Commuters in 2021 ... . More than 24,000 faculty and staff work at our schools, colleges, and administrative units. Diversity is a source of strength, creativity, and innovation at UW–Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinions enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals.

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Holiday work, Full time,

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